If You Can't Grow On This Stuff, Find A New Hobby!
The One is a completely new and novel anabolic compound, exclusively produced by Applied Nutriceuticals. It is an oral prohormone of dihydrotestosterone (DHT), a compound that produces effects 3 to 5 times more potent than testosterone.
The One also helps modulate estrogen levels and acting as an aromatase inhibitor, disallowing the conversion of androgens to estrogen. It also employs a 17-alpha alkylated molecule for greater oral bioavailability. Lastly, The One can significantly lower SHBG (a binding hormone that reduces the amount of free testosterone) levels, allowing for more active product to reach skeletal muscle.
Users will experience:
- Rapid lean body mass gains - typical users report 10-15 lb. gains in the first 2-3 weeks
- Overall hardening effect to physique
- Increased vascularity
- Increased strength
- Dramatically enhanced speed & coordination
- Mood-enhancing effect
- Increased fat metabolism
Product Characteristics:
- The One is an oral prohormone of Dihydrotestosterone (DHT), a compound thatproduces effects 3 to 5 times more potent than testosterone on the androgen receptor.
- The One can inhibit the action of estrogens by acting as a competitive antagonistand/or decreasing the mRNA-induced transcription of estrogenic effects post-binding.
- The One can also act like an aromatase inhibitor, disallowing the conversion ofandrogens to estrogen.
- The One activates GLUT-4 receptors in skeletal muscle, increasing glycogen uptake.
- The One employs a 17-alpha alkylated molecule for greater oral bioavailability.
- The One can significantly lower SHBG levels, allowing for more active product to reach skeletal muscle.
ADMINISTRATION/DOSAGE:
- Effective dose: 67.5 - 90 mg/day (3-4 capsules) ; DO NOT EXCEED 90 MG/DAY
- Can be taken with or without food; preferably in the AM
- Oral Administration Only
- 4-5 week administration period; do not exceed 5 weeks duration
TRAINING:
- 8-15 rep sets- 75-85% of 1RM Max for maximal hypertrophy
- Train 3-5 days per week
- Use Heavy Compound Exercises and Variations
- Squats
- Deadlifts
- Pull-Ups w/ multiple grips
- Bench Press
Mechanism of Action/Function:
Absorption
- User ingests compound orally
- Digestion occurs in roughly 20-30 minutes (as with most encapsulated products)
- Compound is absorbed by the duodenum and jejunum of the small intestine, and then is displaced into the hepatic portal vein, (a special blood vessel leading from the digestive tract to the liver) where the compound must undergo the "first pass" through the liver and survive hepatic metabolism.
- Methylation allows the compound to survive the first pass through the liver, protecting the molecule from hepatic enzymatic degradation.
- After first pass, the compound is distributed into the inferior vena cava, and then to the heart for systemic distribution.
Distribution:
- The heart pumps the active compound into all different areas of the body during the distribution phase. As is the case with most compounds, SHBG (steroid hormone binding globulin) can remove active compounds from systemic distribution before they reach their target organ (in this case, skeletal muscle).
- Binding proteins such as SHBG are rendered fairly inactive in this situation with the active ingredient in The One, because it is one of only a few compounds that does not carry an actual 3-keto group; it carries a 3-oxime group instead.
- Research has dictated that oximes have little or no binding affinity to SHBG in the blood stream, allowing for more free active substrate to reach their target (the androgen receptor (AR) in skeletal muscle). In essence, the 3-oxime "protects" the molecule from being bound (see graph below) leaving more active substrate in the blood to target skeletal muscle.
Metabolism:
- Once The One reaches skeletal muscle, it must interact with specific target androgen receptors to exert the desired effect of increased protein synthesis and increased nitrogen retention.
- Under normal circumstances, DHT is quickly deactivated in the blood by 3a-HSD into 5alpha-androstan-3a,17b-diol, a weak androgen, and its access to target skeletal muscle tissue is restricted.
- There is some evidence that the 3-oxime substituted for 3-keto group may slow this deactivation, allowing for greater binding of the molecule to the AR.
- Oximes are a group of compounds with the general formula R¹R²CNOH, where R1 constitutes an organic side chain, and R2 is another organic group. This forms a ketoxime.
- Oximes exist as two geometric stereoisomers: A syn-isomer and an anti-isomer.
- Oximes are formed by the action of hydroxylamine on ketones.
Receptor Binding:
- Because the evidence suggests that active DHT may not be metabolized by 3a-HSD into the weaker 5-alpha-androstan-3a,17b-diol within the skeletal muscle because of the oxime, there is a very good chance that fairly large amounts of DHT will actually bind to the AR in skeletal muscle.
- DHT has a 3 to 5 times greater binding potency on the androgen receptor than testosterone, so the resulting effect from The One is a very powerful growth stimulus on skeletal muscle.
- Androgens can act in a genomic (transcriptive, from direct AR binding) or non-genomic (non-AR binding) fashion on target cells.
- Some examples of non-genomic effects: increased IGF-1 expression, displacement of estrogen and progesterone from receptor sites, displacement of aromatase, and increased uptake of calcium in the sarcoplasmic reticulum.
Genomic Effects and MOA:
- The AR has four functional regions: a hinge region containing a nuclear localization signal, a carboxy-terminal ligand-binding domain (AF-2 site), an amino terminal regulatory domain (AF-1 site) and a DNA-binding domain composed of two zinc fingers.
- ARs that are not ligated are located primarily in the cytoplasm, and are bound to heat shock proteins (HSPs). HSPs stabilize the tertiary structure of the AR, permitting androgen binding.
- When The One binds the AR, there is a resulting dissociation of HSPs from the AR, allowing for dimerization (to be held together by molecular force) of the AR and subsequent tyrosine kinase phosphorylation, resulting in translocation (movement) of the AR to the nucleus.
- When the AR translocates inside the nucleus, it binds androgen response elements located in the enhancer and promoter areas of target genes. This results in the consequential assembly of regulatory proteins, and the creation of an active complex for transcription.
- The regulatory proteins form a cross-bridge with the AR, the RNA polymerase, and the pre-initiation complex. Specific coactivators begin transcription by recruiting protein clusters to DNA that change the chromatin scaffolding to a form that is more active for transcription.
- The resulting activated transcription results in synthesis of mRNA, which is signaled by ribosomes to produce specific proteins. Changes in specific cell proteins follow, which in turn mediate growth responses, nitrogen balance, and protein synthesis, among other things.
Excretion:
- The compound is removed from the body via excretion, through the kidneys via glomelular filtration.
FAQ's:
Q: What is The One, and what does it do?
A: The One is 17a-methyl-etioallocholan-17b-ol-3-hydroxyimine, a novel prohormone by Applied Nutriceuticals. Usage of The One can yield the following positive benefits:
- Rapid lean body mass gains - typical users report 0.75 lb./day gains for first 2-3 weeks
- Overall hardening effect to physique
- Increased vascularity
- Increased strength
- Dramatically enhanced neural function (coordination) as DHT is the predominant androgen in neural function
- Mood-enhancing effect
- Lipolytic effect (increases fat metabolism)
Q: I am a drug-tested athlete, can I take The One
A: It is not advisable. Although the active ingredient in The One is not specifically named on any banned lists, it may cause a positive result for related preparations that are.
Q: I have heard that The One is a DHT derivative, and DHT can cause prostate and hair loss issues. Is this true?
A: This is a myth. If you are prone to male pattern baldness (MPB), you are going to lose your hair anyway; it's more a matter of when rather than if. Although prohormones in general have the potential to accelerate hair loss in men prone to MPB, testers of The One have reported no such effects. As for prostate issues, The One is a carefully derived DHT analog that has been formulated to have very limited androgenic potential; meaning that The One has minimal action on the prostate and hairline. DHT actually is NOT necessarily (and read this carefully) the main promoter of prostate issues; it is actually estrogen and other metabolites.
Q: What is the recommended daily dosage, and how long should I run The One for?
A: 45 - 90 mg/day (2-4 capsules) ; DO NOT EXCEED 90 MG/DAY
- Can be taken with or without food; preferably in the AM
- Oral Administration Only
- 4-5 week administration period; do not exceed 5 weeks duration
Q: What type of training, nutrition, and supplements should I use along with The One?
A: Take Complete Balance Multi-Vitamin/Multi-Mineral
- Ensures that all essential vitamins and minerals are being taken in daily
B: Take Omega Essentials EFA/DHA at 3-5 grams per day
- Strengthens cell membranes
- Enhances insulin sensitivity
- Synergistic with the GLUT-4 translocating ability of The One
- Enhances healthy HDL/LDL profiles
C: Take Bio-Mend Anti-Oxidant formula
- High ORAC Value
- Protects cellular membranes
- Protects transcriptional factors (mRNA and DNA)
D: Milk Thistle
- Hepatoprotectant - protects liver health
E: In general, maintain a healthy diet and lifestyle:
- Drink Plenty of water- at least 64 oz. per day
- Ingest at least 1 gram of protein per lb. of body weight daily
- Sleep at least 7 hours per night
- Eat lots of fruits and vegetables
- Eat lots of complex carbs
- Eat 5-6 smaller protein and carb-rich meals throughout the day
- Increase calories to at least 500 Kcal/day over your normal intake
- BCAAs and Creatine will be helpful
- Avoid alcohol and tobacco
Q: Does The One require Post-Cycle Therapy (PCT)?
A: YES. BELOW ARE TIPS TO MAXIMIZE RECOVERY & MAINTAIN GAINS POST-CYCLE:
Take 2nd Gear by Applied Nutriceuticals as directed (Aromatase inhibitor that increases free testosterone with minimal endocrine suppression while protecting and promoting healthy liver function.)
- 6-Bromodioine 50mg
- Milk Thistle
- Avena Sativa
- I3-C (Indole 3-Carbinol)
- Prevent calcium leakage from Sarcoplasmic Reticulum
- Helps to maintain cell membrane integrity
- Helps to maintain healthy HDL/LDL levels
- Helps to protect mRNA and DNA
- Helps to keep adequate nutrient profile
- Increases cell membrane strength
- Helps establish/maintain healthy lipid profiles
- Increases insulin sensitivity
DRIVE as directed on label
- Increases Cyclic AMP (cAMP) which in turn can have stimulatory effects on spermatogenesis
- Increases free testosterone
- Increases thyroid output
- Increases calcium uptake and decreases calcium leakage from sarcoplasmic reticulum (SR) increased calcium storage in SR helps to mediate a non-hormonal anabolic response
- Increases free testosterone
- Increases GH output
Q: Can The One interact with other medications?
A: Potentially- please consult your physician before undertaking any diet or supplementation program.
Q: Can I stack The One with other prohormones?
A: It is not advisable. Higher doses of prohormones have diminishing returns
Q: Can I pulse The One?
A: Yes. Below are three suggested dosing protocols:
- For every-other-day dosing: 67.5 mg for 3 weeks; 90 mg for 2 weeks; M W F. Follow with post cycle recommendations stated above.
- For 2 on 2 off: 67.5 mg for 3 weeks; 90 mg for 2 weeks; Mon/Tues, Fri/Sat. Follow with post cycle recommendations stated above.
- For 2 weeks on/2 off: 67.5 mg for two weeks, take 2 weeks off, repeat. egular pct post, following recommendations in write-up
Q: I am 16, can I take The One?
A: The One is not recommended for anyone under the age of 21.
Q: Can women take The One?
A: We do not recommend that women take The One, as virilizing effects that include deepening of the voice, facial hair, and clitoral enlargement may occur.
2nd Gear is a rapid-acting competitive aromatase inhibitor. It is designed to prevent the aromatization of androgens to estrogen; normalizing estrogen while promoting increased testosterone production. It is predominantly used for accelerated increases of endogenous testosterone back to normal levels after the use of suppressive anabolic / androgenic compounds.
However, the aforementioned positive attributes of 2nd Gear also allow it to be a useful supplemental anabolic, as it nicely complements many herbal and hormonal anabolics in promoting even greater enhancements in hardness and definition than the individual products alone.
EFFECTS:
- Lowered conversion of testosterone to estrogen
- Can increase testosterone levels
- Lowered water retention
- Effective as an aromatase-inhibitor during a cycle
- Effective for increasing testosterone as a stand-alone or in conjunction with other anabolics.
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