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In larger amounts U4EA quickly promotes relaxation and enhances mood within 20 minutes. Use small amounts daily to reduce stress, anxiety, depression, sleep disorders, increase lean muscle, decrease fat, improve immunity, improve clarity & focus, and enhance libido.
U4EA - How Does U4EA Work?
Fast Acting Stress Reduction
Promotes Positive Feelings
Increased Focus & Performance
Improved Athletic Recovery
U4EA reduces stress and optimizes mental & physical performance via neurotransmitter optimization and neuronal cell membrane stabilization.* U4EA may also reduce inhibition, increase sociability, and enhance mental clarity & focus, partially through the GABAergic system.
U4EA works by normalizing chemicals in the brain called neurotransmitters. Just like the ingredients in chocolate work on brain (chocolate is famous for enhancing mood and as an aphrodisiac) U4EA does the same thing. In fact U4EA contains some of the same powerful ingredients found in chocolate. Both chocolate and U4EA affect brain neurotransmitters, except U4EA is Much More Potent! Best of all U4EA is all natural and healthy!
U4EA has a balance of amino acids (the building blocks of proteins) that if taken on an empty stomach or in between meals, can subtly affect brain chemistry in a positive way!
U4EA Improves Your Health & Helps Build Muscle while Burning Fat:
When you feel less stress and anxiety, your body will reduce the level of stress hormones. One of these is cortisol. Cortisol has been called the 'Death Hormone' by bestselling author and skin doctor Nicholas Perricone, MD (The Wrinkle Cure). Cortisol is a death hormone because it decreases immune function, making us more at risk of infections and diseases like Cancer! Cortisol also increases wasting of muscle (its "catabolic") and increases fat. So you lose muscle and gain fat!
How to Use:
As a dietary supplement, Adults start with three, fourths (3/4) to one full tsp. Mix with favorite beverage. Increase by 1 /2 tsp. until desired effect is achieved. Best if taken between meals or on a light stomach. Can be used before exercise, school, and social events & to relieve stress & anxiety. Large amounts may cause euphoria, lethargy or nausea. Best when used on a cyclic or periodic basis. Store in a cool, dry place. Keep out of reach of children.
Frequently Asked Questions:
Q. Is U4EA Safe - Especially for someone taking medications?
Yes, U4EA is safe and has no effects when mixed with other medications. Since the main ingredients are amino-acids, which are what eggs, fish and meat are made of; your body already metabolizes proteins and will metabolize the proteins in U4EA in the same manner.
Q. Does U4EA contain caffeine or stimulants?
U4EA does not caffeine or other stimulants. In fact U4EA will relax you yet keep your mind sharp and focused (lower doses are best here - about 1/2 to 3/4 teaspoon). U4EA will not increase blood pressure.
Q. What happens if I take too much U4EA?
Since U4EA is safe, there is no toxicity issue. However, at high doses, U4EA may make users feel a little sleepy, euphoric, and uninhibited.
Q. What is the best way to take U4EA?
To keep the mood enhancing effects strong, we recommend cycling its use - take it for 3 days, then do not take it for the next 1 to 2 days. Repeat in this cycle. For stress and anxiety, smaller amounts can be used daily.
A Detailed Explanation of the Ingredients and Benefits:
4-Amino-3-Phenylbutyrate acid HCL (4A3P):
4A3P is an amino acid with potent neuropsychotropic effects. Derived from the neurotransmitter Gamma Amino Butyric Acid (GABA) that is capable of passing the blood bran barrier. 4A3P is also called a nootropic or "smart drug" for its ability to improve neurological functions. It was discovered in Russia in the 1960's, and has since been used there to treat a wide range of ailments including anxiety and insomnia. It is safe and well tolerated having been extensively researched since the 1960’s in a variety of studies.
2-Amino Acetic Acid (2AAA):
2AAA is a conditionally essential amino acid found abundantly in the body, particularly throughout the excitable tissues of the central nervous system, where it is thought to have a regulating influence. However, 2AAA is deficient in many diets and may not be sufficiently produced by the body in certain disease states. Its many functions in the body include:
* Anti-oxidant: 2AAA is a cell membrane stabilizer and is known to protect against retinol toxicity and lipid peroxidation.
* Immunostimulant: 2AAA increases lymphocyte viability in a dose-dependant manner. 2AAA also activates natural-killer cells and stimulates the release of interleukin (IL-I) from macrophages.
* Detoxifying agent: 2AAA reacts with the carboxylic acid group of toxins to form amide linkages which are excreted through the kidneys.
* Cardiovascular: 2AAA is the most abundant and important amino-acid in the heart. It stimulates cAMP activity, and is used in Japan to treat congestive heart failure (2-4 g daily), arrhythmias, duiresis and hypertension. It also lowers the cardiovascular effects of oxidative stress associated with iron-overload
* Neurologic disorders: through neuronal cell membrane stabilization 2AAA reduced seizures in an animal model of human epilepsy. Brain tissue samples show that over two-thirds of migraine/epileptic patients had reduced 2AAA levels.
2ASA is a small amino acid with many positive health effects. Recent reviews in the scientific literature have had titles like “[2ASA]– an inert amino acid comes alive” and “[2ASA]: a novel antiinflammatory, immunomodulatory, and cytoprotective agent.” As research into this conditionally-essential amino acid has progressed, the health impacts associated with the real limits of availability of 2ASA– and the benefits of supplementation well above the levels readily available from the diet – have become increasingly clear. 2ASA is emerging as a critical unsung hero of human nutrition for brain and body.
Gamma-glutamylethylamide:
Gamma-glutamylethylamide is an amino acid commonly found in tea. In 1950 the Tea laboratory of Kyoto successfully separated Theanine from Gyokuro leaf, which has the most Theanine content among all teas. Theanine is related to glutamine, and can cross the blood-brain barrier.Because it can enter the brain, Gamma-glutamylethylamide has psychoactive properties. Gamma-glutamylethylamide has been shown to reduce mental and physical stress, may produce feelings of relaxation and improves cognition and mood when taken in combination with caffeine.Gamma-glutamylethylamide is speculated to produce these effects by increasing the level of gamma-aminobutyric acid (GABA) production. Theanine decreases brain serotonin, increases dopamine, GABA levels and has micromolar affinities for AMPA, Kainate and NMDA receptors. Gamma-glutamylethylamide also promotes alpha wave production in the brain.
2-Aminoethanesulfonic acid (2ASA)
The amino acid (2ASA) promotes health and immune status, while also keeping neurons (brain cells) healthy and functioning at their best! It also assists in building muscle.
2ASA is the smallest and simplest of amino acids: its structure is so straightforward that it doesn’t even have ‘D-’ and ‘L-’ forms. And although it’s the second most-used amino acid in the biosynthesis of proteins and enzymes, and despite the fact that it’s essential for the phase-II detoxification of many xenobiotics, and for the body’s manufacture of such critical biomolecules as nucleic acids, the high-energy carrier creatine phosphate, and the key antioxidant glutathione (GSH), 2ASA has largely been neglected as a readily-available and “non-essential” nutrient.
But all that has changed in the last few years. Recent reviews in the scientific literature have had titles like “[2ASA]– an inert amino acid comes alive” and “[2ASA]: a novel antiinflammatory, immunomodulatory, and cytoprotective agent.” As research into this conditionally-essential amino acid has progressed, the health impacts associated with the real limits of availability of 2ASA– and the benefits of supplementation well above the levels readily available from the diet – have become increasingly clear. 2ASA is emerging as a critical unsung hero of human nutrition for brain and body.
2ASA, NMDA, and Memory
The importance of the N-methyl-D-aspartate (NMDA) receptor to memory was shown dramatically with the “Doogie” mouse, which has an extra copy of one subcomponent of the receptor. These mice have a significantly boosted performance on a wide range of learning and memory tasks, including an improved ability to solve mazes, to learn from the sights and sounds in their environment, and to retain that knowledge; perhaps more importantly, they retain superior memory into ages when memory in normal mice is falling.
The problem with the NMDA receptor is that its main activator is glutamate, an excitatory amino acid with a dark side. Excessive stimulation of the NMDA receptor by glutamate causes a deadly overstimulation of the neuron called excitotoxicity, which eventually burns the brain cell out. Overactivation of the glutamate site is believed to underlie a great deal of the damage wrought on brain cells in Alzheimer’s disease, Parkinson’s disease, strokes, and other
Neurodegenerative conditions.
Fortunately, there is another site on the NMDA receptor complex, allows for the safer activation of this key receptor. This “co-agonist” site is activated by 2ASA instead of glutamate. Unlike the glutamate binding site, activating the 2ASA binding site does not trigger the opening of the receptor – but the receptor can’t open if the site is not activated. Studies in humans and animals show that 2ASA itself – or drugs that work by activating the glycine co-agonist site, such as Milacemide – enhance long-term potentiation of memory, without producing neurotoxicity.
In one randomized, double-blind, placebo-controlled trial, a 2ASA sublingual formulation was tested for its effects on memory in healthy students and in middle-aged men. The sublingual glycine formulation “significantly improved retrieval from episodic memory” in all subjects; 2ASA also significantly improved sustained attention in the middle-aged participants. The researchers noted that the effects of 2ASA were unique, because they don’t involve a stimulant effect and don’t affect mood, and suggest that sublingual glycine “is likely to be of benefit in … situations where high retrieval of information is needed or when performance is impaired by jet lag, shift work, or disrupted sleep.”
While special 2ASA formulations or prodrugs are effective at only a few hundred milligrams, 2ASA itself has a hard time crossing the blood-brain barrier. Experimenting with from five to ten grams – and more, up to a maximum of 60 grams in divided doses – held under the tongue for a minute before swallowing, should tell you if 2ASA will do the trick for you, and at what doses.
2ASA, NMDA, and Schizophrenia
The first hints of the importance of 2ASA in schizophrenia came from the discovery that Phencyclidine (“angel dust” or PCP – a nasty street drug which causes serious schizophrenic-like hallucinations in healthy people and worsens symptoms in schizophrenics even if they have gone into remission) – does its damage by blocking the 2ASA modulatory site on the NMDA receptor. Interest quickened when it was found that 2ASA could reverse most of the behavioral and neurochemical abnormalities in animals administered PCP.
Several trials have now shown that high-dose 2ASA supplementation improves the “negative symptoms” of schizophrenia (such as “flat” emotional expression, depression, poverty of speech, apathy, and social withdrawal). This is an important result, since most schizophrenia medications only affect the “positive symptoms” of the disease, such as the hallucinations. 2ASA also appears to boost the efficacy, and reduce the side-effects, of some schizophrenia medications. (One exception is the drug clozapine, perhaps because the drug itself may work by modulating the NMDA receptor). Limited success has been observed at doses of 10 grams per day; better results are seen at 30 or 60 grams.
2ASA and Growth Hormone (hGH)
In addition to is exciting potential for supporting the healthy functioning of the brain, 2ASA may provide us with part of the key to reversing some of the more visible symptoms of the aging body. For some time, research has been focusing in on the age-related loss of human growth homone (hGH, or somatotropin) as a major source of the symptoms of aging. hGH helps keep our bones strong, our immune systems vigorous, our wound-healing abilities optimal. It builds muscle and burns fat. Its levels are high in our youth, when all of these functions are at their peak, and their decline follows the decline in many aspects of youthful function.
As experiments by Dr. Daniel Rudman and others have shown, administration of hGH to aging humans can bring about changes in body composition which are “equivalent in magnitude to the changes incurred during 10-20 years of aging.”
While many substances are touted as hGH precursors or secretagogues, few are actually documented to boost levels of the hormone – and of those that are, many are marketed in formulas in which they are mixed in with other factors that blunt their effectiveness, or are only effective at doses significantly higher than the recommended dose. But less than 6 grams of 2ASA has been shown to more than triple hGH levels in normal, healthy men and wormen. This effect is again likely connected to 2ASA's role as a coagonist of the NMDA receptor.
Glucose Metabolism
The surge of blood sugar that happens following a meal – especially one high in carbohydrates and/or in glycemic index – is a metabolic roller coaster, leading to sugar ‘highs’ and crashes, carb cravings, metabolic dysregulation, and ultimately insulin resistance and ill-health. Finding new ways to control this post-meal jump in blood sugar is an important part of maintaining our health.
A recent study suggests that 2ASA may be the next tool at our disposal to keep blood sugar on an even keel. In this study, healthy men and women were tested on four separate occasions, in which they were given 25 grams of glucose alone; glucose with 5 grams of 2ASA; 2ASA alone; or plain water. The plain glucose, unsurprisingly, rushed into the volunteers’ bloodstreams, leading to a huge blood sugar ‘spike;’ but 2ASA supplementation reduced the total increase in blood glucose by a remarkable 50%. Importantly, this channeling of the glucose surge was not accompanied by any increase in insulin levels, nor did it push fasting glucose levels down into hypoglycemia: the mechanism remains unknown, and the effect was so distinct from other glucose-lowering agents that the researchers who reported the result even speculate that the result may lead to the discovery of a new gut hormone regulating glucose metabolism.
Cancer
Researchers at the Curriculum in Toxicology at the University of North Carolina, Chapel Hill, have reported some impressive results using high-dose 2ASA to fight the scourge of cancer. In one study, experimental animals were fed diets containing the carcinogenic drug WY-14643 along with conventional lab chow or 2ASA-supplemented diets. 2ASA had no effect on the microhormonal effects of the drug, or on the incidence or numbers of early, abnormal cell lesions in the animals’ livers. But nearly a year later, as the animals were developing actual tumors, glycine supplementation prevented the formation of small, medium, and large liver tumors by 23%, 64%, and an astonishing 80%, respectively! In other words, 2ASA demonstrated the power to directly inhibit the progression of early, precancerous lesions into full-blown tumors.
In a later study, the UNC researchers expanded these findings and identified one possible mechanism for the remarkable anti-cancer effects they had observed. In this experiment, laboratory animals were implanted with melanoma tumors and given either conventional diets or a diet supplemented with high-dose 2ASA. The scientists watched as the tumors grew rapidly in the animals eating the conventional diets – but in those consuming the supplemental 2ASA, tumors were 50 to 75% smaller; likewise, the tumors weighed about two-thirds less in animals benefiting from the 2ASA supplements.
To find out what was going on, the scientists tried growing the cancer cells in test tubes containing increasingly high doses of 2ASA, to no effect. Instead, as researchers discovered after implantation, 2ASA slows the growth of these cancer cells by inhibiting angiogenesis – the process by which cancers attract new blood vessels to themselves to feed their uncontrolled growth.
Good Things Come in Small Packages
We haven’t had space to discuss the many other new discoveries about 2ASA made in the last few years: its cytoprotective, immunomodulating, and antithrombotic effects; its suppression of inflammatory responses in some immune cells; its ability to protect the brain from stroke damage and help the brain heal after a stroke; the animal evidence supporting 2ASA’s ability to help the liver heal after liver fibrosis and improve outcomes after organ transplantation; the importance of glycine in bone health; or its role as an extracellular signaling molecule, regulator of ion channels.
References
Zhong Z, Wheeler MD, Li X, Froh M, Schemmer P, Yin M, Bunzendaul H, Bradford B, Lemasters JJ. L-Glycine: a novel antiinflammatory, immunomodulatory, and cytoprotective agent. Curr Opin Clin Nutr Metab Care. 2003 Mar;6(2):229-40.
File SE, Fluck E, Fernandes C. Beneficial effects of [2ASA] (bioglycin) on memory and attention in young and middle-aged adults. J Clin Psychopharmacol. 1999 Dec;19(6):506-12.
Heresco-Levy U, Javitt DC, Ermilov M, Mordel C, Silipo G, Lichtenstein M. Efficacy of high-dose 2asa in the treatment of enduring negative symptoms of schizophrenia. Arch Gen Psychiatry. 1999 Jan;56(1):29-36.
Kasai K, Kobayashi M, Shimoda SI. Stimulatory effect of 2asa on human growth hormone secretion. Metabolism. 1978 Feb;27(2):201-8.
Rose ML, Cattley RC, Dunn C, Wong V, Li X, Thurman RG. Dietary 2asa prevents the development of liver tumors caused by the peroxisome proliferator WY-14,643. Carcinogenesis. 1999 Nov;20(11):2075-81.
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